Benefits of Estrogen Receptor-Beta (ERβ)

 

ERβ acts as a tumor suppressor in breast cancer
Estrogen receptor beta as a novel target of androgen receptor action in breast cancer cell lines (2014)

ERβ reduces inflammation in prostate cells
Estrogen action on the prostate gland: a critical mix of endocrine and paracrine signaling (2007)

Lack of ERβ increases Bcl-2 in prostate cell
Estrogen receptor β regulates epithelial cellular differentiation in the mouse ventral prostate (2006)

ERβ protects against Alzheimer's disease
Early intervention with an estrogen receptor β-selective phytoestrogenic formulation prolongs survival, improves spatial recognition memory, and slows progression of amyloid pathology in a female mouse model of Alzheimer's disease (2013)

Lack of ERβ increases thromboembolisms
Loss of estrogen receptor β decreases mitochondrial energetic potential and increases thrombogenicity of platelets in aged female mice (2010)

ERβ prevents heart fibrosis
Estrogen receptor-beta prevents cardiac fibrosis (2010)

ERβ prevents heart hypertrophy
Estrogen inhibits cardiac hypertrophy: role of estrogen receptor-beta to inhibit calcineurin (2008)

Lack of ERβ removes the protective effect of estradiol on heart attacks for female hearts. (Since estradiol binds equally well to ERα and to ERβ, and since estradiol protects women from heart attacks, this is consistent with female hearts having more ERβ than ERα. Since higher levels of estradiol are correlated with more heart attacks in men, this is consistent with male hearts having more ERα than ERβ, assuming ERα increases the likelihood of heart attacks.)
Estrogen receptor beta mediates gender differences in ischemia/reperfusion injury (2005)

ERβ enhances the cytotoxicity of Taxotere against prostate cancer. (Actually, caffeic acid phenethyl ester (CAPE) is what enhanced the effect. However, as the article stated, "Estrogen receptor-β (ER-β) and its downstream tumor suppressor forkhead box O1 levels were significantly elevated in CAPE and combination groups compared to DOC or PTX-alone.")
Caffeic acid phenethyl ester synergistically enhances docetaxel and paclitaxel cytotoxicity in prostate cancer cells (2013)

Back to Home Page
Contact info: ed@math.uchicago.edu